CNTFR (NM_147164) Purified Human Protein

Species: Human Expression Host: Human 293HEK cells Expression cDNA Clone and Sequence Recombinant protein was produced with TrueORF clone, RC200487. Click on the TrueORF clone link to view cDNA and protein sequences. Tag: C-terminal MYC/DDK Predicted MW: 38.7 kDa Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining Mass Spec Validation: This protein has been positively validated by MS/MS by Dr. Robert Moritz at The Institute of Systems Biology. Concentration: >50 ug/mL as determined by microplate BCA method Buffer and Storage: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. Protein Families: Druggable Genome Protein Pathways: Cytokine-cytokine receptor interactionJak-STAT signaling pathway

Protein Data

RefSeq: NP_671693	RefSeq Size: 2055	RefSeq ORF: 1119
LocusID: 1271	Cytogenetic: 9p13
Synonyms : MGC1774
Summary: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May

Researchers who bought this clone have also purchased:

Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens ciliary neurotrophic factor receptor (CNTFR), transcript variant 1 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens ciliary neurotrophic factor receptor (CNTFR), transcript variant 1 as transfection-ready DNA Related Lysate from OriGene • Transient overexpression lysate of ciliary neurotrophic factor receptor (CNTFR), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • CNTFR - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • CNTFR - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Cntfr - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • CNTFR - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Cntfr - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related Primer Pair qSTAR qPCR primer pairs against Homo sapiens gene CNTFR

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Protein	Full Length Protein A domain of the protein Description of domain...
Tag	C-fusion N-fusion     Tag Description:
DNA or protein sequence of the final product
Preferred Expression Host	HEK293 E. coli Insect Cells Yeast
The main application with the purified protein	R&D reagent Cell-based Assay Animal Study Other, please specify:
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