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Home Recombinant Human Proteins All HEXB Proteins

HEXB (NM_000521) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP300465 Recombinant protein of human hexosaminidase B (beta polypeptide) (HEXB), 20 ug (Larger pack size?) $680 In Stock
TA314004 Rabbit polyclonal anti-HEXB antibody $325 In Stock
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC200465. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:62.9 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: TransmembraneDruggable Genome
Protein Pathways: Other glycan degradationAmino sugar and nucleotide sugar metabolismGlycosaminoglycan degradationGlycosphingolipid biosynthesis - globo seriesGlycosphingolipid biosynthesis - ganglio seriesMetabolic pathwaysMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_000512 RefSeq Size: 1857 RefSeq ORF: 1671
LocusID: 3074 Cytogenetic: 5q13  
Synonyms : ENC-1AS; HEL-248
Summary: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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