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Home cDNA Clone TrueORF All Acer2 ORF Clones

Acer2 (NM_139306) Mouse cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
MG216452 Acer2 (GFP-tagged) - Mouse alkaline ceramidase 2 (Acer2), (10ug), 10µg
$420
2-3 weeks
TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
Clone Modification
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TrueORF Data for MG216452
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Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 828 bp
Predicted Protein MW: kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data
RefSeq: NM_139306.2, NP_647467
RefSeq Size: RefSeq ORF: 828
Synonyms : 2410116I05Rik; Asah3l; CRG-L1; maCER2
LocusID: 230379 Cytogenetic: 4 C4|4
Summary: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (By similarity). Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates (By similarity). Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine (By similarity). Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface (By similarity). May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. [UniProtKB/Swiss-Prot Function]

 

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