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Home MicroRNA 3' UTR Clones

FGFR4 (NM_002011) 3’-UTR clone in pMirTarget

Specifications Citations Related Products Product Documents
Cat. No. Description Price Availability  
SC206264 3`UTR clone of fibroblast growth factor receptor 4 (FGFR4) transcript variant 1 for miRNA target validation $495.00 4 weeks * Add to Shopping Cart
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Also for FGFR4 (NM_002011)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
OriGene TrueClone Data
Vector:pMirTarget Insert Size: 464 Restriction Site: SgfI-MluI
Sequence Data:Insert Sequence
OTI Disclaimer:Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Product Components:The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.

Reference Data
RefSeq:NM_002011.3
Synonyms :CD334; JTK2; TKF
Locus ID:2264
Summary:The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008].

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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