Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses
Cancer Prevention Research, Jan 2012; 5: 122 - 137.
[HSPB1
]
Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells
Mol. Cancer Res., Jan 2012; 10: 133 - 142.
[SREBF1
]
Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
Cancer Res., Jan 2012; 72: 527 - 536.
[AR
]
CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling
J. Biol. Chem., Jan 2012; 287: 1198 - 1209.
[Cnr2
]
3’-UTR reporter clones for miRNA target validation
Assay-ready Luc-UTR constructs for 20,000 human genes
The 3’-UTR plasmids provide a convenient solution for quantitative assessment of the inhibitory effect between miRNAs and their potential target genes. The 3’-UTR sequence of a gene of interest was cloned downstream of the firefly luciferase gene. The chimeric transcript level is regulated by its interaction with miRNA(s), which results in varied luciferase activity quantifiable by a colorometric assay
Interaction between miRNA and UTR Reduced luciferase expression
No interaction between miRNA and UTR No effect on luciferase expression
Features:
Join OriGene webinar on comprehensive tools for miRNA function study and expression analysis
