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Home cDNA Clone TrueORF All ABL1 ORF Clones

ABL1 (NM_005157) Human cDNA ORF Clone

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Cat. No. Description Price Availability  
RG220600 ABL1 (GFP-tagged) - Human c-abl oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant a, 10µg   
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TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
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TrueORF Data for RG220600
Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 3393 bp
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTranscription FactorsDruggable Genome
Protein Pathways: ErbB signaling pathwayCell cycleAxon guidanceNeurotrophin signaling pathwayPathogenic Escherichia coli infectionPathways in cancerMore Pathways >>

Reference Data
RefSeq Explanation: NM_005157.3, NP_005148 RefSeq Size: 5384 RefSeq ORF: 3393
Synonyms : ABL; bcr/abl; c-ABL; c-ABL1; JTK7; p150; v-abl
LocusID: 25 Cytogenetic: 9q34.1
Gene Summary: This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014].


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