OriGene - GABBR2 (NM_005458) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG219404

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 2826 bp Predicted Protein MW: 101.6 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	GPCR Transmembrane Druggable Genome
Protein Pathways:	Neuroactive ligand-receptor interaction

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_005458.5, NP_005449	RefSeq Size: 5786	RefSeq ORF: 2826
Synonyms : GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
LocusID: 9568	Cytogenetic: 9q22.1
Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

GABBR2 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC222756	Mus musculus gamma-aminobutyric acid (GABA) B receptor, 2 (Gabbr2) as transfection-ready DNA	10 ug	$1130	7 weeks
MR222075	Myc-DDK-tagged ORF clone of Mus musculus gamma-aminobutyric acid (GABA) B receptor, 2 (Gabbr2) as transfection-ready DNA	10 ug	$1130	7 weeks
MG222075	GFP-tagged ORF clone of Mus musculus gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2) as transfection-ready DNA	10 ug	$1240	Next day

GABBR2 Rat Clones

SKU	Description	Amount	Price	Shipping
RN214644	NativeORF clone of Rattus norvegicus gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2) as transfection-ready DNA	10 ug	$1129	Next day
RR214644	Myc-DDK-tagged ORF clone of Rattus norvegicus gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2) as transfection-ready DNA	10 ug	$1129	7 weeks

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GABBR2 (NM_005458) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

GABBR2 Mouse Clones

GABBR2 Rat Clones

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