OriGene - IL12RB1 (NM_153701) Human ORF cDNA Clone

Western Blot Validated

TrueORF Data for RG216444

Vector:	pCMV6-AC-GFP Change vector?	Tag: C-terminal TurboGFP	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1146 bp Predicted Protein MW: 39.6 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transmembrane Druggable Genome
Protein Pathways:	Cytokine-cytokine receptor interaction Jak-STAT signaling pathway

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_153701.1, NP_714912	RefSeq Size: 1881	RefSeq ORF: 1146
Synonyms : CD212; IL-12R-BETA1; IL12RB
LocusID: 3594	Cytogenetic: 19p13.1
Summary: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

IL12RB1 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC221222	Mus musculus interleukin 12 receptor, beta 1 (Il12rb1) as transfection-ready DNA	10 ug	$890	Next day
MR220916	Myc-DDK-tagged ORF clone of Mus musculus interleukin 12 receptor, beta 1 (Il12rb1) as transfection-ready DNA	10 ug	$890	6 weeks
MG220916	GFP-tagged ORF clone of Mus musculus interleukin 12 receptor beta 1 (Il12rb1) as transfection-ready DNA	10 ug	$980	3 weeks

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IL12RB1 (NM_153701) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

IL12RB1 Mouse Clones

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