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Home cDNA Clone TrueORF All CTNNA1 ORF Clones

CTNNA1 (NM_001903) Human cDNA ORF Clone

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RG201766 CTNNA1 (GFP-tagged) - Human catenin (cadherin-associated protein), alpha 1, 102kDa (CTNNA1), 10µg   
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TA150041 2H8, Anti-tGFP monoclonal antibody, 100µl $248 In Stock
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0 2 weeks
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Also for CTNNA1 (NM_001903)
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TrueORF Data for RG201766
Vector: pCMV6-AC-GFP   Change vector? Tag: C-terminal TurboGFP
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 2721 bp
Restriction Sites: SgfI-RsrII     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Adherens junctionTight junctionLeukocyte transendothelial migrationPathways in cancerEndometrial cancerArrhythmogenic right ventricular cardiomyopathy (ARVC)

Reference Data
RefSeq Explanation: NM_001903.2, NP_001894 RefSeq Size: 3778 RefSeq ORF: 2721
Synonyms : CAP102
LocusID: 1495 Cytogenetic: 5q31.2 Domains: Vinculin
Gene Summary: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. [UniProtKB/Swiss-Prot Function]


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