OriGene - GGT1 (NM_013430) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in Lenti and other vectors is also available.

Cat. No.	Description	Vector	Price	Availability
RC223640L1	Lenti ORF clone of Human gamma-glutamyltransferase 1 (GGT1), transcript variant 3 , Myc-DDK-tagged	pLenti-C-Myc-DDK pLenti-C-mGFP pCMV6-AC-GFP	$910	2 Weeks
TR30022	Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns)		$360	In Stock

TrueORF Data for RC223640

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1710 bp Predicted Protein MW: 61.2 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transmembrane Protease
Protein Pathways:	Taurine and hypotaurine metabolism Selenoamino acid metabolism Cyanoamino acid metabolism Glutathione metabolism Arachidonic acid metabolism Metabolic pathways

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_013430.2, NP_038347	RefSeq Size: 2381	RefSeq ORF: 1710
Synonyms : CD224; D22S672; D22S732; GGT; GGT 1; GTG
LocusID: 2678	Cytogenetic: 22q11.23	Domains: G_glu_transpept
Summary: The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

GGT1 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC200936	Mus musculus gamma-glutamyltransferase 1 (Ggt1) as transfection-ready DNA	10 ug	$165	Next day
MR208958	Myc-DDK-tagged ORF clone of Mus musculus gamma-glutamyltransferase 1 (Ggt1) as transfection-ready DNA	10 ug	$680	Next day
MG208958	GFP-tagged ORF clone of Mus musculus gamma-glutamyltransferase 1 (Ggt1) in a GFP expression vector	10 ug	$750	3 weeks

GGT1 Rat Clones

SKU	Description	Amount	Price	Shipping
RN207237	NativeORF clone of Rattus norvegicus gamma-glutamyltransferase 1 (Ggt1) as transfection-ready DNA	10 ug	$683	4 weeks
RR207237	Myc-DDK-tagged ORF clone of Rattus norvegicus gamma-glutamyltransferase 1 (Ggt1) as transfection-ready DNA	10 ug	$683	4 weeks

Don't see the species of your interest?
Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

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GGT1 (NM_013430) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

GGT1 Mouse Clones

GGT1 Rat Clones

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