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Home CRISPR-CAS9 KN208223

LYRM7 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN208223 LYRM7 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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SKU Description Donor Vector Price Availability  
KN208223RB LYRM7 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN208223LP LYRM7 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN208223BN LYRM7 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN208223, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN208223G1, LYRM7 gRNA vector 1 in pCas-Guide vector
KN208223G2, LYRM7 gRNA vector 2 in pCas-Guide vector
KN208223D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001293735NM_181705NR_121658XM_033003
Synonyms: C5orf31; MC3DN8; MZM1L
Summary: Inner mitochondrial membrane complex III (CIII) is the main enzyme complex in the mitochondrial respiratory chain, and Rieske Fe-S protein (UQCRFS1) is the last catalytic subunit added to the complex. The protein encoded by this gene is a nuclear-encoded mitochondrial matrix protein that stabilizes UQCRFS1 and chaperones it to the CIII complex. Defects in this gene are a cause of mitochondrial complex III deficiency, nuclear type 8. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

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Diagram-Gene Editing RecombII


 

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