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Home CRISPR-CAS9 KN202488

BLNK - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN202488 BLNK - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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SKU Description Donor Vector Price Availability  
KN202488RB BLNK - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN202488LP BLNK - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN202488BN BLNK - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN202488, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN202488G1, BLNK gRNA vector 1 in pCas-Guide vector
KN202488G2, BLNK gRNA vector 2 in pCas-Guide vector
KN202488D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001114094NM_001258440NM_001258441NM_001258442NM_013314NR_047680NR_047681NR_047682NR_047683XM_011539728XM_017016159
Synonyms: AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
Summary: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].

Learn more about CRISPR?

Diagram-Gene Editing RecombII


 

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