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Home CRISPR-CAS9 KN200051

DYNLRB1 - human gene knockout kit via CRISPR

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Specifications  Citations  Validation Data  FAQ
SKU Description Price Availability Manual  
KN200051 DYNLRB1 - human gene knockout kit via CRISPR $1200 4 Weeks Manual PDF Add to Shopping Cart
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SKU Description Donor Vector Price Availability  
KN200051RB DYNLRB1 - human gene knockout kit via CRISPR RFP-BSD 1290 4 Weeks
KN200051LP DYNLRB1 - human gene knockout kit via CRISPR Luciferase-Puro 1290 4 Weeks
KN200051BN DYNLRB1 - human gene knockout kit via CRISPR mBFP-Neo 1290 4 Weeks
Add to Shopping Cart

Comparing to KN200051, the above kits contain:

  • Identical gRNA vectors
  • Identical LHA & RHA
  • Different donor cassette
kn_donor_diagram
Kit Components
KN200051G1, DNCL2A gRNA vector 1 in pCas-Guide vector
KN200051G2, DNCL2A gRNA vector 2 in pCas-Guide vector
KN200051D, donor vector containing Left and right homologous arms and GFP-Puro functional cassette.
   
GE100003, scramble sequence in pCas-Guide vector

Disclaimer
The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data
RefSeq: NM_001281727NM_001281728NM_001281729NM_014183NM_177953NM_177954NR_104032
Synonyms: BITH; BLP; DNCL2A; DNLC2A; ROBLD1
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].

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Diagram-Gene Editing RecombII


 

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