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Anti-NFKB2 Antibody EPR4686


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against NF-kappa-B p100 (NFKB2)
100ul $325 3-7 Days
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Also for NFKB2 (NM_001077493)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA recombinant protein fragment corresponding to residues in human NF-kappa-B p100 was used as an immunogen.
Clone NameEPR4686 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (NFKB2), transcript variant 3
Alternative NameLYT-10; LYT10; p52
Database LinkNP_001070961
Entrez Gene 4791 Human
Entrez Gene 18034 Mouse
FunctionNF-kappa-B p100 has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. It is activated by a wide variety of stimuli, such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B p100 has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B p100 has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. NF-kappa-B p100 and p105 proteins are processed to produce the active p50 and p52 NF-kappa-B subunits, respectively. However, the NF-kappa-B p100 and p105 proteins serve regulatory functions and should not be considered exclusively as precursor forms. The most abundant activated form of NF-kappa-B is a heterodimer of the p50 or p52 subunit bound to the RELA subunit. Other NF-kappa-B complexes, consisting of hetero- and homodimers of p50, p52, RELA, REL, and RELB, have also been detected. NF-kappa-B complexes are inhibited by I-kappa-B proteins, NFKBIA or NFKBIB, which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by the kinases IKBKA or IKBKB marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. The activated NF-kappa-B complex translocates into the nucleus and binds DNA at kappa-B-binding motifs, such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (1).
Related PathwayTranscription Factors MAPK signaling pathwayPathways in cancer

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Western blot - NFkB p100 / p52 antibody [EPR4686]; All lanes : Anti-NFkB p100 / p52 [EPR4686] antibody at 1/10000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : ECV-304 cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 97 kDa.Observed band size : 110 kDa .


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