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Anti-ITGAV Antibody EPR5583


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310958 Rabbit Monoclonal antibody against CD51 / Integrin alpha-V (ITGAV) 100ul $325 In Stock
LC428633 ITGAV HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the intracellular domain of human CD51 / Integrin alpha-V was used as an immunogen.
Clone NameEPR5583 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Predicted MW Explanation 86, 116 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens integrin subunit alpha V (ITGAV), transcript variant 2
Alternative NameCD51; MSK8; VNRA; VTNR
Database LinkNP_001138471
Entrez Gene 3685 Human
Entrez Gene 16410 Mouse
Entrez Gene 296456 Rat
FunctionIntegrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing CD51 / Integrin alpha-V undergoes post-translational cleavage to yield disulfide-linked heavy chain (125 kDa) and light chain (25 kDa), which combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the CD51 / Integrin alpha-V, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction (1).
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Focal adhesionECM-receptor interactionCell adhesion molecules (CAMs)Regulation of actin cytoskeletonPathways in cancerSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Integrin alpha V + beta 6 antibody [EPR5583]; All lanes : Anti-Integrin alpha V + beta 6 antibody [EPR5583] at 1/1000 dilution.Lane 1 : A549 cell lysates.Lane 2 : A431 cell lysates.Lane 3 : C6 cell lysates.Lane 4 : RAW264.7 cell lysates.Lane 5 : PC12 cell lysates.Lane 6 : NIH 3T3 cell lysates.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 86, 116 kDa.

Assay Image
Other-Anti-Integrin alpha V + beta 6 antibody [EPR5583](TA310958); Equilibrium disassociation constant (KD)..

FC Image
Flow Cytometry - Anti-Integrin alpha V + beta 6 antibody [EPR5583]; TA310958 at 1/10 dilution staining Integrin alpha V + beta 6 in permeabilized A549 cells by Flow cytometry (red) or a rabbit IgG (negative) (green).


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