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Anti-FZD6 Antibody EPR7279
Also for FZD6 (NM_001164615)
|A synthetic peptide corresponding to residues in human Frizzled-6 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens frizzled family receptor 6 (FZD6), transcript variant 2|
|FZ-6; FZ6; HFZ6; NDNC10|
|Frizzled-6 represents a member of the 'frizzled' family, which are 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-6 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. It functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis (1). |
Wnt Signaling Pathway
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Western blot - Anti-Frizzled 6 antibody [EPR7279]; All lanes : Anti-Frizzled 6 antibody [EPR7279] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HT 29 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 79 kDa.
Other-Anti-Frizzled 6 antibody [EPR7279](ab128916); Equilibrium disassociation constant (KD)..