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Home Antibody All anti-CTLA4 antibodies

Anti-CTLA4 Antibody EPR1476

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310369
  • Rabbit Monoclonal antibody against CD152 / CTLA4
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC421970) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for CTLA4 (NM_001037631)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus in human CD152/CTLA4 was used as an immunogen.
Clone NameEPR1476 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 25 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 2
Alternative NameCD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Database LinkNP_001032720
Entrez Gene 1493 Human
Entrez Gene 12477 Mouse
Entrez Gene 63835 Rat
FunctionCD152 / CTLA4 is a member of the immunoglobulin superfamily that transmits an inhibitory signal to T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in CD152 / CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Related PathwayTransmembraneDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayAutoimmune thyroid disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CTLA4 antibody [EPR1476]; All lanes : Anti-CTLA4 antibody [EPR1476].Lane 1 : Jurkat cell lysate.Lane 2 : Raji cell lysate.Lane 3 : Human CTLA4 full length protein .Predicted band size : 25 kDa.

 

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