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Anti-CTLA4 Antibody EPR1476
Also for CTLA4 (NM_001037631)
|A synthetic peptide corresponding to residues on the N-terminus in human CD152/CTLA4 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 2|
|CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12|
Entrez Gene 1493 Human
Entrez Gene 12477 Mouse
Entrez Gene 63835 Rat
|CD152 / CTLA4 is a member of the immunoglobulin superfamily that transmits an inhibitory signal to T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in CD152 / CTLA4 have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.|
|TransmembraneDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayAutoimmune thyroid disease|
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Western blot - Anti-CTLA4 antibody [EPR1476]; All lanes : Anti-CTLA4 antibody [EPR1476].Lane 1 : Jurkat cell lysate.Lane 2 : Raji cell lysate.Lane 3 : Human CTLA4 full length protein .Predicted band size : 25 kDa.