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Anti-CAMK2B Antibody EPR6685(B)
Also for CAMK2B (NM_001220)
|A synthetic peptide corresponding to residues in human CaMKII was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
|WB, ASSAY, FC
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for ICC/IF,IHC-P or IP.
|Homo sapiens calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant 1|
|CAM2; CAMK2; CAMKB|
|Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).|
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - Anti-CaMKII antibody [EPR6685(B)]; All lanes : Anti-CaMKII antibody [EPR6685(B)] at 1/1000 dilution.Lane 1 : Human pancreas lysate.Lane 2 : Human fetal kidney lysate.Lane 3 : HeLa lysate.Lane 4 : Jurkat lysate.Lane 5 : SH SY5Y lysate.Lane 6 : BxPC3 lysate.Lane 7 : C6 lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51-73 kDa.
Other-Anti-CaMKII antibody [EPR6685(B)](ab126789); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-CaMKII antibody [EPR6685(B)]; ab126789 at 1/10 dilution staining CaMKII in permeabilized C6 cells by Flow cytometry (red) compared with a rabbit IgG negative control (green).