Home Antibody All anti-C2 antibodies
Also for C2 (NM_001145903)
|Recombinant fragment corresponding to a region within amino acids 265 and 642 of Complement C2 (Uniprot ID#P06681)|
|Human (Predicted: Pig, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Pig (84%), Bovine (80%)
|Homo sapiens complement component 2 (C2), transcript variant 2|
Entrez Gene 717 Human
|Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.|
|Secreted ProteinProteaseDruggable Genome Complement and coagulation cascadesSystemic lupus erythematosus|
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Sample(30 ug whole cell lysate). A: 293T. B: A431 . C: H1299. D: HeLa S3 . E: Hep G2 . F: MOLT4 . G: Raji . 7.5% SDS PAGE. TA308854 diluted at 1:1000
Immunofluorescence analysis of methanol-fixed A431, using Complement C2(TA308854) antibody at 1:200 dilution.