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Home Antibody All anti-C2 antibodies

Anti-C2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308854
  • Rabbit Polyclonal antibody to Complement C2 (complement component 2)
100ul 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 265 and 642 of Complement C2 (Uniprot ID#P06681)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Pig, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 83kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Pig (84%), Bovine (80%)

Reference Data

Target NameHomo sapiens complement component 2 (C2), transcript variant 2
Alternative NameARMD14; CO2
Database LinkNP_001139375
Entrez Gene 717 Human
FunctionComponent C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Related PathwaySecreted ProteinProteaseDruggable Genome Complement and coagulation cascadesSystemic lupus erythematosus

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WB Image
Sample(30 ug whole cell lysate). A: 293T. B: A431 . C: H1299. D: HeLa S3 . E: Hep G2 . F: MOLT4 . G: Raji . 7.5% SDS PAGE. TA308854 diluted at 1:1000
IF Image
Immunofluorescence analysis of methanol-fixed A431, using Complement C2(TA308854) antibody at 1:200 dilution.

 

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