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Anti-COL1A2 Antibody


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SKU Description Amount Price Availability*  
TA308423 Rabbit polyclonal antibody to Collagen I alpha2 (collagen, type I, alpha 2) 100ul $325 3 Weeks
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1057 and 1366 of Collagen I alpha2 (Uniprot ID#P08123)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Rhesus Monkey) Concentration0.4mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:1000-1:10000
Predicted MW Explanation 129kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens collagen type I alpha 2 (COL1A2)
Alternative NameOI4
Database LinkNP_000080
Entrez Gene 1278 Human
Entrez Gene 700359 Monkey
FunctionThis gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
Related PathwayDruggable Genome Focal adhesionECM-receptor interaction

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WB Image
COL1A2 antibody [C2C3], C-term detects COL1A2 protein by western blot analysis. A. 30 ug 293T whole cell extract. B. 30 ug whole cell extract of GFP-human COL1A2-transfected 293T cells (partial). 10 % SDS-PAGE. COL1A2 antibody [C2C3], C-term (TA308423) di

IF Image
COL1A2 antibody [C2C3], C-term detects COL1A2 protein at cytoplasm by immunofluorescent analysis. Sample: NIH-3T3 cells were fixed in ice-cold MeOH for 5 min. Green: COL1A2 protein stained by COL1A2 antibody [C2C3], C-term (TA308423) diluted at 1:500. Blu


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