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Also for COL1A2 (NM_000089)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1057 and 1339 of Collagen I alpha2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens collagen, type I, alpha 2 (COL1A2)|
|This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]|
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Sample (30 ug of whole cell lysate) A: 293T B: A431 (anti-COL1A2 antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed A431, using Collagen I alpha2(anti-COL1A2 antibody) antibody at 1:200 dilution.