Home Antibody All anti-CBFA2T2 antibodies
Also for CBFA2T2 (NM_005093)
|Recombinant fragment corresponding to a region within amino acids 401 and 604 of CBFA2T2 (Uniprot ID#O43439)|
|Human (Predicted: Mouse, Chicken, Rat)
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (95%), Chicken (80%), Rat (95%)
|Homo sapiens core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2), transcript variant 2|
|EHT; MTGR1; p85; ZMYND3|
Entrez Gene 9139 Human
Entrez Gene 12396 Mouse
Entrez Gene 296293 Rat
|In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]|
|Transcription Factors |
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Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. TA308048 diluted at 1:1000.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2(TA308048) antibody at 1:200 dilution.