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Home Antibody All anti-FGFR2 antibodies

Anti-FGFR2 Antibody EPR5180

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307869
  • Rabbit monoclonal antibody against FGF Receptor 2(clone EPR5180)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400050) , 20ug
100ul $325 In Stock
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WB(1)
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Also for FGFR2 (NM_000141)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human FGF Receptor 2 was used as an immunogen.
Clone NameEPR5180 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IHC-P.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1
Alternative NameBBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Database LinkNP_000132
FunctionFGF Receptor 2 is a member of the fibroblast growth factor receptor family, whose amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGF Receptor 2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
Related Pathway
MAPK signaling pathway

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WB Image
Western blot - FGFR2 antibody [EPR5180]; All lanes : Anti-FGFR2 antibody [EPR5180] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : K562 cell lysate.Lane 5 : T47-D cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 92 kDa.Observed band size : 145 kDa .

 

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