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Anti-FGFR2 Antibody EPR5180
Also for FGFR2 (NM_000141)
|A synthetic peptide corresponding to residues in the extracellular domain of human FGF Receptor 2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens fibroblast growth factor receptor 2 (FGFR2), transcript variant 1|
|BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25|
|FGF Receptor 2 is a member of the fibroblast growth factor receptor family, whose amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGF Receptor 2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.|
MAPK signaling pathway
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Western blot - FGFR2 antibody [EPR5180]; All lanes : Anti-FGFR2 antibody [EPR5180] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : K562 cell lysate.Lane 5 : T47-D cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 92 kDa.Observed band size : 145 kDa .