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Anti-GRK6 Antibody EPR2046(2)
Also for GRK6 (NM_002082)
|A synthetic peptide corresponding to residues in human GRK6 was used as an immunogen.|
|Mouse, Human (Does not react with: Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:250 - 1:500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 2|
Entrez Gene 2870 Human
Entrez Gene 26385 Mouse
|G protein-coupled receptor kinases (GRK’s) phosphorylate ligand-activated G protein-coupled receptors on serine and threonine residues within the carboxy-terminal tail and intracellular loops, a process that is accompanied by the recruitment of beta-Arrestins (1). GRK6 is a member of the guanine nucleotide-binding protein GRK subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors, thus initiating their deactivation (2).|
|Protein KinaseDruggable Genome Chemokine signaling pathwayEndocytosis|
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Western blot - GRK6 antibody [EPR2046(2)]; All lanes : Anti-GRK6 antibody [EPR2046(2)] at 1/1000 dilution.Lane 1 : U937 cell lysate.Lane 2 : Ramos cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 66 kDa.