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Anti-TNFSF4 Antibody EP1168Y
Also for TNFSF4 (NM_003326)
|A synthetic peptide corresponding to residues on the C-terminus of human OX40L was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:10000 - 1:50000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4)|
|CD134L; CD252; GP34; OX-40L; OX4OL; TXGP1|
|Tumor necrosis factor receptor superfamily member 4 (OX40, CD134) is a membrane receptor found on activated CD4+ and CD8+ T cells and B cells (1). OX40 binds to OX40 ligand (OX40L) and other TNF receptor-associated factors (TNAF2, TRAF3, TRAF5). OX40-OX40L complex produces CD28 independent co-stimulatory signals. OX40 is involved in the pathologic cytokine storm associated in certain viral infection, such as H4N1 bird flu. OX40 starts a survival signal to the T-cell preventing activation-induced apoptosis, but up regulates cytokine production. Inhibition of OX40 using OX40-immunoglobulin has been linked to reduction of immune overreaction without affecting the viral clearance (2). |
Cytokine-cytokine receptor interaction
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Western blot - CD134 / OX40 antibody [EP1168Y]; All lanes : Anti-CD134 / OX40 antibody [EP1168Y] at 1/50000 dilution.Lane 1 : recombinant CD134 / OX40 at 0.01 µg.Lane 2 : recombinant CD134 / OX40 at 0.005 µg.Secondary.goat anti-rabbit-HRP at 1/1000 dilution.Predicted band size : 30 kDa.Observed band size : 50 kDa .