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Anti-MKNK1 PHOSPHO Antibody EPR2370
Also for MKNK1 (NM_198973)
|A synthetic peptide corresponding to residues in human Mnk1 Phospho (pT385) was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens MAP kinase interacting serine/threonine kinase 1 (MKNK1), transcript variant 2|
|Mnk1 (MAPK-interacting kinase 1) is a MAPK-regulated kinase in the CAMK Serine/Threonine protein kinase family that phosphorylates the initiation factor eIF4E (1, 2). Mnk1 is phosphorylated in response to type I IFNs in an Erk/MAPK-dependent manner (1). Furthermore, it is activated by the p38 kinases and kinases in the Erk pathway (2). Phosphorylation of Threonine 385 activates this kinase (2). Mnk1 may also play a role in the response to environmental stress and cytokines (2).|
MAPK signaling pathway
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Western blot - MNK1 (phospho T385) antibody [EPR2370]; All lanes : Anti-MNK1 (phospho T385) antibody [EPR2370] at 1/1000 dilution.Lane 1 : HeLa cell lysate, untreated.Lane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 µg per lane.Predicted band size : 51 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - MNK1 (phospho T385) antibody [EPR2370]; Immunohistochemical analysis of MNK1 (phospho T385) expression in paraffin-embedded Human colon tissue using TA307346 at 1/250 dilution.