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Anti-Cdkn1b Antibody EPFHCR16a


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against p27/Kip1(clone EPFHCR16a)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401318) , 20ug Explanation
100ul $325 3-7 Days
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Also for Cdkn1b (NM_004064)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human p27/Kip1 was used as an immunogen.
Clone NameEPFHCR16a IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
Alternative NameCDKN4; KIP1; MEN1B; MEN4; P27KIP1
Database LinkNP_004055
Entrez Gene 1027 Human
Functionp27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. It is an inhibitor of cyclinE-Cdk2 complex, cyclinA-Cdk2 and cyclinD1-Cdk4 (1), and a positive regulator of cyclin D-dependent kinases such as Cdk4 (2). It plays a pivotal role in the control of cell proliferation and the loss of p27/Kip1 function may lead to carcinogenesis (4). The function of p27/Kip1 is regulated by phosphorylation and degradation events. Phosphorylation by hKIS on Serine 10 signals the nuclear export to the cytoplasm (3), while phosphorylation by Cdk2 on Threonine 187 results in ubiquitylation and degradation of p27/Kip1 (2).
Related PathwayDruggable Genome ErbB signaling pathwayCell cyclePathways in cancerProstate cancerChronic myeloid leukemiaSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - p27 KIP 1 antibody [EPFHCR16a]; All lanes : Anti-p27 KIP 1 antibody [EPFHCR16a] at 1/1000 dilution.Lane 1 : MCF-7 cell lysates .Lane 2 : SH-SY5Y cell lysates .Lysates/proteins at 10 ug per lane.Predicted band size : 22 kDa.


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