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Anti-Cdkn1b Antibody EPFHCR16a
Also for Cdkn1b (NM_004064)
|A synthetic peptide corresponding to residues in human p27/Kip1 was used as an immunogen.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)|
|CDKN4; KIP1; MEN1B; MEN4; P27KIP1|
|p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. It is an inhibitor of cyclinE-Cdk2 complex, cyclinA-Cdk2 and cyclinD1-Cdk4 (1), and a positive regulator of cyclin D-dependent kinases such as Cdk4 (2). It plays a pivotal role in the control of cell proliferation and the loss of p27/Kip1 function may lead to carcinogenesis (4). The function of p27/Kip1 is regulated by phosphorylation and degradation events. Phosphorylation by hKIS on Serine 10 signals the nuclear export to the cytoplasm (3), while phosphorylation by Cdk2 on Threonine 187 results in ubiquitylation and degradation of p27/Kip1 (2).|
Senescence and Autophagy
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Western blot - p27 KIP 1 antibody [EPFHCR16a]; All lanes : Anti-p27 KIP 1 antibody [EPFHCR16a] at 1/1000 dilution.Lane 1 : MCF-7 cell lysates .Lane 2 : SH-SY5Y cell lysates .Lysates/proteins at 10 µg per lane.Predicted band size : 22 kDa.