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Anti-BAG2 Antibody EPR3567
Also for BAG2 (NM_004282)
|A synthetic peptide corresponding to residues in the N-terminus of human Bag-2 was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||FC: 1:60, ICC: 1:100 - 250, IHC: 1:100, IP: 1:10, WB: 1:1000 - 5000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens BCL2-associated athanogene 2 (BAG2)|
|BAG-2 is a member of a family of BAG-related proteins (BAG-2, BAG-3, BAG-4, BAG-5). BAG-family proteins may play a role in providing opportunities for specification and diversification of Heat Shock Protein (Hsp70) chaperone functions. Hsp70 family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. BAG-2 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner (1). |
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Western blot - BAG2 antibody [EPR3567]; All lanes : Anti-BAG2 antibody [EPR3567] at 1/5000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : HepG2 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 24 kDa.Observed band size : 24 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - BAG2 antibody [EPR3567]; ab79406, at 1/100 dilution, staining BAG2 in human ovarian carcinoma by Immunohistochemistry using paraffin-embedded tissue.