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Anti-SRC Antibody EGTR103
|A synthetic peptide corresponding to residues to human Src was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||IHC-P: 1:100 - 1:250; WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (SRC), transcript variant 1|
|ASV; c-SRC; p60-Src; SRC1|
|Src is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).|
EGFR1 Signaling Pathway
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Western blot - Anti-Src antibody [EGTR103]; All lanes : Anti-Src antibody [EGTR103] at 1/1000 dilution.Lane 1 : U87-MG cell lysate .Lane 2 : SH-5YSY cell lysate .Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.