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Home Antibody All anti-SRC antibodies

Anti-SRC Antibody EGTR103

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SKU Description Amount Price Availability*  
TA307221
  • Rabbit monoclonal antibody against Src(clone EGTR103)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417311) , 20ug Explanation
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues to human Src was used as immunogen.
Clone NameEGTR103 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsIHC-P: 1:100 - 1:250; WB: 1:1000 - 1:10000
Predicted MW Explanation 60 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens SRC proto-oncogene, non-receptor tyrosine kinase (SRC), transcript variant 1
Alternative NameASV; c-SRC; p60-Src; SRC1
Database LinkNP_005408
Entrez Gene 6714 Human
Entrez Gene 20779 Mouse
Entrez Gene 83805 Rat
FunctionSrc is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome ErbB signaling pathwayEndocytosisVEGF signaling pathwayFocal adhesionAdherens junctionTight junctionMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Src antibody [EGTR103]; All lanes : Anti-Src antibody [EGTR103] at 1/1000 dilution.Lane 1 : U87-MG cell lysate .Lane 2 : SH-5YSY cell lysate .Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.

 

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