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Home Antibody All anti-SRC antibodies

Anti-SRC Antibody EGTR103

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307221
  • Rabbit monoclonal antibody against Src(clone EGTR103)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417311) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for SRC (NM_005417)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues to human Src was used as immunogen.
Clone NameEGTR103 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsIHC-P: 1:100 - 1:250; WB: 1:1000 - 1:10000
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (SRC), transcript variant 1
Alternative NameASV; c-SRC; p60-Src; SRC1
Database LinkNP_005408
FunctionSrc is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).
Related Pathway
Adherens junction
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis

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WB Image
Western blot - Anti-Src antibody [EGTR103]; All lanes : Anti-Src antibody [EGTR103] at 1/1000 dilution.Lane 1 : U87-MG cell lysate .Lane 2 : SH-5YSY cell lysate .Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 60 kDa.

 

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