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Home Antibody All anti-MME antibodies

Anti-MME Antibody EP2998

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SKU Description Amount Price Availability*  
TA307129
  • Rabbit monoclonal antibody against CD10 (clone EP2998 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416064) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on human CD10 was used as an immunogen.
Clone NameEP2998 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens membrane metallo-endopeptidase (MME), transcript variant 1bis
Alternative NameCALLA; CD10; NEP; SFE
Database LinkNP_009218
Entrez Gene 4311 Human
FunctionThe cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin, and substance P (1). It is expressed in a wide variety of epithelial and non-epithelial tissues, but its most significant application is in the diagnosis and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, and some hematopoietic tumors (2). It is also known to be a marker of endometrial stromal cells, and was reported to be expressed in cells immediately surrounding the neoplastic glands invading the myometrium (3).
Related PathwayTransmembraneProteaseDruggable Genome Renin-angiotensin systemHematopoietic cell lineageAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CD10 antibody [EP2998]; Lane 1 : Anti-CD10 antibody [EP2998] at 1/1000 dilution.Lane 2 : Anti-CD10 antibody [EP2998] at 1/10000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : LNCap cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 100 kDa .
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