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Anti-MME Antibody EP2998


Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against CD10 (clone EP2998 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416064) , 20ug Explanation
100ul 325 3-7 Days
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Also for MME (NM_007287)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on human CD10 was used as an immunogen.
Clone NameEP2998 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens membrane metallo-endopeptidase (MME), transcript variant 1bis
Alternative NameCALLA; CD10; NEP; SFE
Database LinkNP_009218
Entrez Gene 4311 Human
FunctionThe cluster designation (CD) antigens are cell surface molecules first defined on human leukocytes and later found to be expressed by a variety of human cell types in both normal and pathologic states. The common acute lymphoblastic leukemia antigen (CALLA/CD10) is a single-pass type II transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors important for signal transduction including the enkephalins, bombesin, and substance P (1). It is expressed in a wide variety of epithelial and non-epithelial tissues, but its most significant application is in the diagnosis and classification of certain types of malignant lymphoma and leukemia. CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt's lymphoma, and some hematopoietic tumors (2). It is also known to be a marker of endometrial stromal cells, and was reported to be expressed in cells immediately surrounding the neoplastic glands invading the myometrium (3).
Related PathwayTransmembraneProteaseDruggable Genome Renin-angiotensin systemHematopoietic cell lineageAlzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - CD10 antibody [EP2998]; Lane 1 : Anti-CD10 antibody [EP2998] at 1/1000 dilution.Lane 2 : Anti-CD10 antibody [EP2998] at 1/10000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : LNCap cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugate at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 100 kDa .


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