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Anti-MELK Antibody EPR3981
Also for MELK (NM_014791)
|A synthetic peptide corresponding to residues in human MELK was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens maternal embryonic leucine zipper kinase (MELK), transcript variant 1|
Entrez Gene 9833 Human
|Maternal embryonic leucine zipper kinase (MELK), a member of the CAMK Serine/Threonine protein kinase family, functions to regulate the cell cycle (1). It serves as a marker for self-renewing multipotent neural progenitors (MNP) (1). MELK interacts in a phosphorylation-dependent manner with the transcription and splicing factor NIPP1, and this interaction can inhibit spliceosome assembly during mitosis (2). An additional substrate of MELK is the zinc finger-like protein ZPR9, which binds tightly to MELK and causes its nuclear accumulation (3). It is also expressed in tissues such as the placenta, kidney, and thymus (4).|
|Protein KinaseDruggable Genome |
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Western blot - MELK antibody [EPR3981]; All lanes : Anti-MELK antibody [EPR3981] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lane 3 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 75 kDa.