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Anti-CAV2 Antibody EPR2220
Also for CAV2 (NM_198212)
|A synthetic peptide corresponding to residues surrounding Tyrosine 19 in human Caveolin 2 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:10, WB: 1:5,000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens caveolin 2 (CAV2), transcript variant 2|
|Caveolins are a family of caveolae-associated integral membrane proteins. Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking (1). Caveolin is a principal component of caveolae membranes. It interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects; however, they differ in their functional interactions with heterotrimeric G proteins, possibly explaining why Caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells, which is strictly dependent on continued treatment with NGF. Both Caveolin-1 and -2 are more abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Robust expression of Caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones (1). |
EGFR1 Signaling Pathway
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Western blot - Caveolin 2 antibody [EPR2220]; Anti-Caveolin 2 antibody [EPR2220] at 1/5000 dilution + HeLa cell lysate at 10 µg.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 18 kDa.Observed band size : 20 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Caveolin 2 antibody [EPR2220]; ab79397 at 1/100 dilution staining Caveolin 2 in human uterus by Immunohistochemistry using paraffin-embedded tissue. Note staining of endothelial cells and smooth muscles.
Immunocytochemistry/ Immunofluorescence - Caveolin 2 antibody [EPR2220]; ab79397 at 1/100 dilution staining Caveolin 2 in HeLa cells by Immunofluorescence.