Home Antibody All anti-CCDC134 antibodies
Also for CCDC134 (NM_024821)
|CCDC134 antibody was raised against a 17 amino acid peptide near the amino terminus of human CCDC134.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens coiled-coil domain containing 134 (CCDC134), transcript variant 1|
Entrez Gene 79879 Human
Entrez Gene 76457 Mouse
Entrez Gene 500909 Rat
|The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.|
|Secreted Protein |
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Western blot analysis of CCDC134 in rat brain tissue lysate with CCDC134 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of CCDC134 in human brain tissue with CCDC134 antibody at 2.5 ug/ml.
Immunofluorescence of CDCC134 in human brain tissue with CDCC134 antibody at 20 ug/mL.