Home Antibody All anti-POFUT1 antibodies
Also for POFUT1 (NM_015352)
|POFUT1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human POFUT1.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens protein O-fucosyltransferase 1 (POFUT1), transcript variant 1|
|DDD2; FUT12; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1|
|POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling. At least two isoforms of POFUT1 are known to exist. This antibody is predicted to not cross-react with POFUT2.|
Delta-Notch Signaling Pathway
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Western blot analysis of POFUT1 in human heart tissue lysate with POFUT1 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunohistochemistry of POFUT1 in human heart tissue with POFUT antibody at 2.5 ug/ml.