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Home Antibody All anti-CBL antibodies

Anti-CBL Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306364
  • Rabbit Polyclonal Cbl Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401588) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for CBL (NM_005188)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCbl antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human cbl.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, IF
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Alternative NameC-CBL; CBL2; FRA11B; NSLL; RNF55
Database LinkNP_005179
FunctionThe mammalian cbl family of ubiquitin ligases consists of three homologs known as cbl (also known as c-Cbl), Cbl-B, and Cbl-3 which share highly conserved a tyrosine-kinase-binding domain, linker and RING finger domain in their amino-terminal halves. Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitin-conjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the cbl family, cbl antibody reacts specifically with cbl. Multiple isoforms of cbl have been reported.
Related Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway

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WB Image
Western blot analysis of cbl in Daudi cell lysate with cbl antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunofluorescence of cbl in human lymph node tissue with cbl antibody at 20 ug/mL.

 

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