Home Antibody All anti-BCAP31 antibodies
Also for BCAP31 (NM_001139441)
|BAP31 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human BAP31.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens B-cell receptor-associated protein 31 (BCAP31), transcript variant 3|
|6C6-AG; BAP31; CDM; DDCH; DXS1357E|
|Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family (1,2). These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18 (3,4). It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria (5). Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death (5).|
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Western blot analysis of BAP31 in Ramos cell lysate with BAP31 antibody at (A) 0.5, (B) 1 and (C) 2ug/ml.
Immunohistochemistry of BAP31 in rat lung tissue with BAP31 antibody at 2 ug/ml.