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Home Antibody All anti-CRMP1 antibodies

Anti-CRMP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306259
  • Rabbit Polyclonal CRMP1 Antibody
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenCRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml; IHC: 2ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens collapsin response mediator protein 1 (CRMP1), transcript variant 1
Alternative NameCRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3
Database LinkNP_001014809
FunctionCollapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis (1). Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity (2). CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain (3); later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth (4). CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons (5).
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CRMP1 in 3T3 cell lysate with CRMP1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of CRMP in human brain tissue with CRMP antibody at 2 ug/ml.

 

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