Home Antibody All anti-TRAF3 antibodies
Also for TRAF3 (NM_003300)
|TRAF3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TRAF3.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 3|
|CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1|
Entrez Gene 7187 Human
Entrez Gene 22031 Mouse
|Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR (5).|
|Druggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayPathways in cancerSmall cell lung cancer|
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Western blot analysis of TRAF3 in 3T3 cell lysate with TRAF3 antibody at (A) 1, and (B) 2 µg/ml.