Home Antibody All anti-C1QTNF1 antibodies
Also for C1QTNF1 (NM_030968)
|CTRP1 (IN) antibody was raised against a 16 amino acid peptide from near the center of human CTRP1.|
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens C1q and tumor necrosis factor related protein 1 (C1QTNF1), transcript variant 1|
|CTRP1; GIP; ZSIG37|
Entrez Gene 114897 Human
Entrez Gene 56745 Mouse
|Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). In obese (ob/ob) mice, RT-PCR analysis showed that mCTRP1 transcripts are seen at substantially higher levels in adipose tissues compared to those of normal mice (3).|
|Secreted ProteinTransmembraneDruggable Genome |
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Western blot analysis of CTRP1 in MDA-MD-361 cell lysate with CTRP1 (IN) antibody at (A) 1 and (B) 2 µg/ml.