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Home Antibody All anti-CASP5 antibodies

Anti-CASP5 Antibody

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SKU Description Amount Price Availability*  
TA306197 Rabbit Polyclonal Caspase-5 Antibody 100ug $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenCaspase-5 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-5.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant b
Alternative NameICE(rel)III; ICEREL-III; ICH-3
Database LinkNP_001129581
Entrez Gene 838 Human
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-ϒ (5).
Related PathwayProteaseDruggable Genome NOD-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Caspase-5 in Ramos cells with Caspase-5 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml.
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