Home Antibody All anti-CASP5 antibodies
Also for CASP5 (NM_001136109)
|Caspase-5 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-5.|
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant b|
|ICE(rel)III; ICEREL-III; ICH-3|
Entrez Gene 838 Human
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-ϒ (5).|
|ProteaseDruggable Genome NOD-like receptor signaling pathway|
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Western blot analysis of Caspase-5 in Ramos cells with Caspase-5 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml.