Home Antibody All anti-AVEN antibodies
Also for AVEN (NM_020371)
|Aven antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Aven.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens apoptosis, caspase activation inhibitor (AVEN)|
|Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.|
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Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/ml.