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Home Antibody All anti-AIFM1 antibodies

Anti-AIFM1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306028
  • Rabbit Polyclonal AIF Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for AIFM1 (NM_001130846)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenAIF antibody was raised against a peptide corresponding to amino acids near the amino terminus of mature human AIF.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1), transcript variant 4
Alternative NameAIF; CMT2D; CMTX4; COWCK; COXPD6; NADMR; NAMSD; PDCD8
Database LinkNP_001124318
Entrez Gene 9131 Human
FunctionApoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed (2).
Related PathwayTransmembraneDruggable Genome Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of AIF in K562 cell lysate with AIF antibody at 1 ug/mL.
IF Image
Immunocytochemistry of AIF in Jurkat cells with AIF antibody at 2 ug/mL.

 

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