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Also for BIRC5 (NM_001012270)
|Survivin antibody was raised against a peptide corresponding to amino acids near the amino terminus of human survivin.|
||ELISA, WB: 1 - 2 ug/ml, ICC: 5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2|
|Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas .|
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Western blot analysis of Survivin in MOLT4 cell lysate with Survivin antibody at (A) 1 and (B) 2 ug/mL.
Immunocytochemistry of Survivin in Jurkat cells with Survivin antibody at 5 ug/mL.