Home Antibody All anti-CCR3 antibodies
Also for CCR3 (NM_001164680)
|CCR3 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human CCR3.|
|Human, Mouse, Rat
|PBS containing 0.02% sodium azide.|
|Immunoaffinity purified IgG
|Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 4|
|CC-CKR-3; CD193; CKR3; CMKBR3|
Entrez Gene 1232 Human
Entrez Gene 12771 Mouse
Entrez Gene 117027 Rat
|Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS (3,4). High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.|
|GPCRTransmembraneDruggable Genome Cytokine-cytokine receptor interactionChemokine signaling pathway|
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Western blot analysis of CCR3 in human spleen tissue lysates with CCR3 antibody at 1 (lane 1) and 2 ug/ml (lane 2), and 2 ug/ml in the presence of blocking peptide (lane 3).
Immunohistochemistry of CCR3 in human spleen tissue with CCR3 antibody at 10 ug/ml.