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Home Antibody All anti-MAP3K8 antibodies

Anti-MAP3K8 Antibody EP1103Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303866
  • Rabbit monoclonal antibody against Tpl2(EP1103Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401593) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for MAP3K8 (NM_005204)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Tpl2 was used as an immunogen.
Clone NameEP1103Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 8 (MAP3K8), transcript variant 1
Alternative Namec-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2
Database LinkNP_005195
FunctionThis gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq].
Related Pathway
MAPK signaling pathway
Toll-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - MAP3K8 antibody [EP1103Y]; Anti-MAP3K8 antibody [EP1103Y] at 1/500 dilution + Jurkat cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP antibody at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.

 

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