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Anti-MAP3K8 Antibody EP1103Y
Also for MAP3K8 (NM_005204)
|A synthetic peptide corresponding to residues in human Tpl2 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
|Homo sapiens mitogen-activated protein kinase kinase kinase 8 (MAP3K8), transcript variant 1|
|c-COT; COT; EST; ESTF; MEKK8; Tpl-2; TPL2|
Entrez Gene 1326 Human
|This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq]. |
|Protein KinaseDruggable Genome MAPK signaling pathwayToll-like receptor signaling pathwayT cell receptor signaling pathway|
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Western blot - MAP3K8 antibody [EP1103Y]; Anti-MAP3K8 antibody [EP1103Y] at 1/500 dilution + Jurkat cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP antibody at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 53 kDa.