Home Antibody All anti-CFL2 antibodies
Also for CFL2 (NM_138638)
| Peptide with sequence C-DIKDRSTLGEK, from the C Terminus of the protein sequence according to NP_068733.1; NP_619579.1.|
|Test: Human, Mouse, Rat. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig
||ELISA: 1:128,000. WB: 0.01-0.03µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens cofilin 2 (muscle) (CFL2), transcript variant 2|
Entrez Gene 1073 Human
Entrez Gene 12632 Mouse
Entrez Gene 366624 Rat
Entrez Gene 490649 Dog
|Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]. |
|Druggable Genome Axon guidanceFc gamma R-mediated phagocytosisRegulation of actin cytoskeleton|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
TA302652 (0.003µg/ml) staining of human muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.