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Home Antibody All anti-MCM7 antibodies

Anti-MCM7 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300922
  • Rabbit Polyclonal Antibody against MCM7
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401787) , 20ug
100ul 379 3-7 Days
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WB(1)
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Also for MCM7 (NM_005916)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human MCM7 was used as an immunogen.
Clone Name IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:5000; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens minichromosome maintenance complex component 7 (MCM7), transcript variant 1
Alternative NameCDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146
Database LinkNP_005907
FunctionThe minichromosome maintenance (MCM7) helicase complex functions to initiate and elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA replication to maintain genomic stability (1). MCM7 is a putative human homologue of yeast CDC47 and a member of the MCM protein family, which has been implicated in the regulatory machinery causing DNA to replicate only once in the S phase. Findings indicate that MCM7 protein together with other MCM proteins participates in the regulation of mammalian DNA replication (2). In HeLa cells, depletion of MCM7 with small-interfering RNA suppressed ultraviolet (UV) light- or aphidicolin-induced hChk1 phosphorylation, and abolished UV-induced S-phase checkpoint activation. These results demonstrate that MCM7 plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in human cells (3).
Related Pathway
Cell cycle

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WB Image
Western blot - MCM7 antibody; Anti-MCM7 antibody at 1/5000 dilution + HeLa cell lysate at 10 µg.Secondary.Goat anti-Rabbit HRP labeled. at 1/2000 dilution.Predicted band size : 81 kDa.Observed band size : 81 kDa.

 

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