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Anti-KLK3 Antibody EP1588Y
Also for KLK3 (NM_001648)
|A synthetic peptide corresponding to residues near the C-terminal of human PSA.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens kallikrein-related peptidase 3 (KLK3), transcript variant 1|
|APS; hK3; KLK2A1; PSA|
Entrez Gene 354 Human
|Prostate-specific antigen (PSA, Kallikrein-3, KLK3) is a serine protease that is usually secreted from the prostate gland and presented in seminal plasma. PSA function in the liquefaction of seminal coagulum, through hydrolysis of the high molecular mass seminal vesicle protein. Its substrates includes semenogelin I & II, fibronectin, insulin-like growth factor binding protein 3 (IGBP3), and laminin (1). Highly expressed by normal and malignant prostate cancer cells, PSA has been implicated in the growth, invasion, and metastasis of prostate cancer cells (2). Therefore, PSA is widely used as a diagnostic marker for prostate cancer. Recently, PSA has been suggested as an endothelial cell-specific inhibitor of angiogenesis (3). |
|Secreted ProteinProteaseDruggable Genome Pathways in cancerProstate cancer|
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Western blot - Prostate Specific Antigen antibody [EP1588Y]; Anti-Prostate Specific Antigen antibody [EP1588Y] at 1/10000 dilution + human prostate carcinoma tissue lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 29 kDa.Observed band size : 34 kDa .
Other-Anti-Prostate Specific Antigen antibody [EP1588Y](TA300883); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Prostate Specific Antigen antibody [EP1588Y]; TA300883, at 1/100 dilution, staining Prostate Specific Antigen in paraffin-embedded human prostate carcinoma tissue by immunohistochemistry.