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Home Antibody All anti-MMP13 antibodies

Anti-MMP13 Antibody EP1263Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300824
  • Rabbit Monoclonal Antibody against MMP13 (Clone EP1263Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400869) , 20ug
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human MMP-13 was used as an immunogen.
Clone NameEP1263Y IsotypeTissue culture supernatant
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC/IF,IHC-Fr,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-Fr,IHC-P or IP.

Reference Data

Target NameHomo sapiens matrix metallopeptidase 13 (collagenase 3) (MMP13)
Alternative NameCLG3; MANDP1; MMP-13
Database LinkNP_002418
FunctionCollagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. Findings demonstrate a unique role of Mmp13 in skeletal development (1). In arthritis, the destruction of fibrillar (type II) collagen is one of the hallmarks, with MMP-1 and MMP-13 being identified as key players in arthritic cartilage. MMP-13, furthermore, has been found in highly metastatic tumors. In contrast to many human MMPs, the MMP-13 distribution pattern is restrictive in normal tissues and selective in pathological conditions. MMP-13 demonstrates versatility in its substrate utilization. In addition to being highly active on type II collagen, MMP-13 cleaves other substrates, mostly macromolecules of the extracellular matrix, but also molecules such as connective tissue (CTGF) and fibrinogen. MMP-13 is controlled at multiple levels: i.e., the expression/synthesis, activation, and inhibition of the active enzyme (3).
Related Pathway

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WB Image
Western blot - MMP13 antibody [EP1263Y]; Anti-MMP13 antibody [EP1263Y] - Carboxyterminal end at 1/500 dilution + HeLa cell lysate at 10 µg.Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 54 kDa.

 

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