Home Antibody All anti-ILK antibodies
|A synthetic peptide corresponding to residues near N-term of human ILK protein was used as immunogen|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:70
|Preservative: 0.01% Sodium azide|
Constituents: 50% Glycerol, 0.05% BSA
|Protein A purified
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens integrin-linked kinase (ILK), transcript variant 1|
|HEL-S-28; ILK-1; ILK-2; P59; p59ILK|
Entrez Gene 3611 Human
Entrez Gene 16202 Mouse
Entrez Gene 170922 Rat
|Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3). |
|Protein KinaseDruggable Genome PPAR signaling pathwayFocal adhesionEndometrial cancer|
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Western blot - Anti-Integrin linked ILK antibody; All lanes : Anti-Integrin linked ILK antibody at 1/1000 dilution.Lane 1 : PC12 cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 51 kDa.