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Home Antibody All anti-ILK antibodies

Anti-ILK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300788
  • Rabbit Polyclonal Antibody against ILK
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401438) , 20ug Explanation
100ul 379 3-7 Days
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WB(1)
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Also for ILK (NM_004517)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near N-term of human ILK protein was used as immunogen
Clone Name IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:70
Predicted MW Explanation 51 kDa
BufferPreservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Protein A purified
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens integrin-linked kinase (ILK), transcript variant 1
Alternative NameHEL-S-28; ILK-1; ILK-2; P59; p59ILK
Database LinkNP_004508
Entrez Gene 3611 Human
Entrez Gene 16202 Mouse
Entrez Gene 170922 Rat
FunctionIntegrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3).
Related PathwayProtein KinaseDruggable Genome PPAR signaling pathwayFocal adhesionEndometrial cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-Integrin linked ILK antibody; All lanes : Anti-Integrin linked ILK antibody at 1/1000 dilution.Lane 1 : PC12 cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 51 kDa.Observed band size : 51 kDa.

 

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