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Anti-CDKN2A Antibody EP435Y
Also for CDKN2A (NM_000077)
|The human recombinant protein p16/INK4a was used as immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500 - 1:2000; FC: 1:10; IP: 1:50
|Does not react with Mouse, Rat. Is unsuitable for ICC or IHC.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for ICC or IHC.
|Homo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1|
|ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;|
|p16 also known as INK4a and CDKN2A (1-2) is a cyclin-dependent kinase inhibitor that specifically inhibits CDK4 and CDK6. Disruption of cyclin-CDK4 complex by p16 prevents phosphorylation of Rb, therefore preventing cell cycle progression from the G1 to S phase (3-4). p16 suppresses cell growth in response to intracellular stimuli. p16 is also know as an important tumor suppressor. Mutations and deletions in p16 have been detected in a wide variety of tumors, especially in Melanoma (5).|
Senescence and Autophagy
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Western blot - p16 INK4a antibody [EP435Y]; Anti-CDKN2A/p16INK4a antibody [EP435Y] at 1/2000 dilution + 293 cell lysate at 10 µg.Predicted band size : 17 kDa.Observed band size : 17 kDa.