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Home Antibody All anti-CDKN2A antibodies

Anti-CDKN2A Antibody EP435Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300632
  • Rabbit Monoclonal Antibody against CDKN2A (Clone EP435Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400022) , 20ug
100ul $325 In Stock
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WB(1)
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThe human recombinant protein p16/INK4a was used as immunogen.
Clone NameEP435Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000; FC: 1:10; IP: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC or IHC.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC or IHC.

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
Functionp16 also known as INK4a and CDKN2A (1-2) is a cyclin-dependent kinase inhibitor that specifically inhibits CDK4 and CDK6. Disruption of cyclin-CDK4 complex by p16 prevents phosphorylation of Rb, therefore preventing cell cycle progression from the G1 to S phase (3-4). p16 suppresses cell growth in response to intracellular stimuli. p16 is also know as an important tumor suppressor. Mutations and deletions in p16 have been detected in a wide variety of tumors, especially in Melanoma (5).
Related Pathway
Apoptosis
Cell cycle
Senescence and Autophagy

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WB Image
Western blot - p16 INK4a antibody [EP435Y]; Anti-CDKN2A/p16INK4a antibody [EP435Y] at 1/2000 dilution + 293 cell lysate at 10 µg.Predicted band size : 17 kDa.Observed band size : 17 kDa.

 

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